Navigating the UAE GP licensing exam can be daunting, but the trial on knowmed.life is a true beacon of guidance. These 20 trial MCQs, covering every domain, are like a personalized training ground. They don’t just test you; they help you understand the very fabric and pattern of the questions you will encounter in real exam.

 

With knowmed.life, you don’t just study for the exam, you study the exam.

 

1. A 24-year-old female presents to the general practice clinic complaining of a persistently depressed mood, anhedonia, severe fatigue, and poor concentration for the past month. During the consultation, you note from her medical records that she has an active history of bulimia nervosa. You decide to initiate antidepressant pharmacotherapy to manage her major depressive disorder. Which of the following antidepressant medications is contraindicated in this patient due to her medical history?

 
 
 
 

2.

A 28-year-old female presents to the emergency department with a severe acute asthma exacerbation. She has already been treated with multiple doses of nebulized albuterol and ipratropium, as well as intravenous methylprednisolone. Despite these initial interventions, she remains in severe respiratory distress, her oxygen saturation is 91% on room air, and her peak expiratory flow (PEF) is 45% of her personal best.
Which of the following is the most appropriate next step in the pharmacologic management of this patient?
 
 
 
 

3.

A 52-year-old female presents to the general practice clinic complaining of severe hot flushes, night sweats, and sleep disruption that have significantly reduced her quality of life over the past 8 months. She reports that her last menstrual period was 14 months ago. Her past medical history is unremarkable, she has never had any surgeries, and she has an intact uterus. After a thorough discussion of the risks and benefits, you and the patient decide to initiate systemic menopausal hormone therapy.
Which of the following is the most appropriate prescribing strategy for this patient?
 
 
 
 

4.

A 42-year-old male presents to the general practice clinic with sudden-onset lower back pain that radiates down his right posterior thigh to below his knee. The pain started a day ago after he lifted a heavy box. On examination, he has a positive straight-leg raising test on the right. He reports no bowel or bladder incontinence, and his motor strength, reflexes, and sensation in the lower extremities are fully intact.
Which of the following is the most appropriate initial management for this patient?
 
 
 
 

5.

A 68-year-old female is brought to the emergency department from a nursing home with a 2-day history of productive cough, fever, and progressive lethargy. Her vital signs are: temperature 38.5°C (101.3°F), heart rate 110 beats/minute, blood pressure 105/65 mm Hg, and respiratory rate 24 breaths/minute. You suspect she has an underlying infection and want to quickly assess her risk for sepsis and poor outcomes using the quick Sequential Organ Failure Assessment (qSOFA) score.
Which of the following clinical findings in this patient is a specific criterion included in the qSOFA score?
 
 
 
 

6.

A 2-year-old girl is brought to the general practice clinic with a 2-day history of frequent watery diarrhea and three episodes of non-bilious vomiting. On examination, she is alert and active but has slightly dry buccal mucous membranes and increased thirst. Her heart rate, blood pressure, and capillary refill are within normal limits.
Which of the following is the most appropriate initial management for this child’s dehydration?
 
 
 
 

7.

A 72-year-old male is brought to the emergency department from an assisted living facility due to progressively decreasing urine output and generalized weakness over the past 48 hours. The caregiver reports that the patient has had a severe diarrheal illness for the last 4 days. On physical examination, his blood pressure is 85/55 mm Hg, heart rate is 112 beats/minute, and he has dry mucous membranes with delayed capillary refill. Laboratory testing shows a blood urea nitrogen (BUN) of 60 mg/dL and a serum creatinine of 2.5 mg/dL.
You suspect acute kidney injury (AKI) secondary to volume depletion. Which of the following urinary diagnostic indices would most strongly support a prerenal etiology for this patient’s AKI?
 
 
 
 

8.

A 65-year-old male presents to the emergency department complaining of severe, deep substernal chest pain, diaphoresis, and nausea. His initial 12-lead ECG demonstrates hyperacute ST-segment elevation in leads II, III, and aVF. On physical examination, his blood pressure is 85/50 mm Hg, and his heart rate is 92 beats/minute. You note prominent distended jugular veins, but auscultation of the lungs reveals completely clear lung fields bilaterally.
Which of the following is the most appropriate next step in the initial hemodynamic management of this patient?
 
 
 
 

9.

A 58-year-old male presents to a emergency department with severe, crushing chest pain of 1-hour duration. His 12-lead ECG shows marked ST-segment elevation in leads V1 to V4, consistent with an acute anterior ST-segment elevation myocardial infarction (STEMI). Your facility does not have percutaneous coronary intervention (PCI) capabilities, and transfer to a PCI-capable center would take an hour. As attending general practitioner you decide to initiate fibrinolytic therapy.
While reviewing the patient’s medical history, which of the following findings represents an absolute contraindication to the administration of fibrinolytic therapy?
 
 
 
 

10.

A 22-year-old female presents to the clinic complaining of generalized weakness. Her body mass index (BMI) is 22 kg/m². On physical examination, you note painless bilateral swelling of her cheeks and significant erosion of the dental enamel on her front teeth. She tearfully admits to recurrent episodes of uncontrollably eating large amounts of food, followed by self-induced vomiting.
Which of the following electrolyte abnormalities is most essential to screen for in this patient?
 
 
 
 

11.

A 45-year-old male presents to the general practice clinic complaining of intense, severe itching that is noticeably worse at night. On physical examination, you observe small erythematous papules alongside fine, wavy, slightly scaly lines up to 1 cm long (burrows) located in the web spaces of his fingers and along his belt line.
Which of the following is the most appropriate diagnostic test to confirm the suspected diagnosis?
 
 
 
 

12.

A 50-year-old male presents to the clinic complaining of severe hearing loss in his right ear that he noticed upon waking up two days ago. He denies any head trauma, recent flying, scuba diving, or exposure to loud noises. He also denies any facial weakness, vertigo, or visual changes. Otoscopic examination reveals a normal external canal and an intact, normal-appearing tympanic membrane. The Weber test lateralizes to the left (unaffected) ear, and the Rinne test demonstrates air conduction greater than bone conduction bilaterally.
Which of the following is the most appropriate empirical pharmacological treatment for this patient’s suspected condition?
 
 
 
 

13.

A 68-year-old female presents to the general practice clinic for a follow-up to discuss the results of her recent dual-energy x-ray absorptiometry (DXA) scan. Her DXA scan reveals a T-score of -2.8 at the lumbar spine. She has no history of fractures. You diagnose her with osteoporosis and decide to initiate first-line antiresorptive therapy with a weekly oral bisphosphonate (e.g., alendronate).
Which of the following instructions is the most appropriate to provide to this patient regarding the administration of this medication?
 
 
 
 

14.

A 24-year-old female presents to the emergency department stating she intentionally ingested an unknown but large quantity of acetaminophen tablets. She currently complains of mild nausea, but her physical examination is otherwise unremarkable. You plan to use the Rumack-Matthew nomogram to estimate her risk of hepatotoxicity and determine if N-acetylcysteine therapy is required.
What is the earliest time post-ingestion that a serum acetaminophen level should be drawn to be accurately plotted on this nomogram?
 
 
 
 

15.

A 10-month-old infant with a known history of unrepaired Tetralogy of Fallot is brought to the emergency department. His parents report that while crying inconsolably, he suddenly developed profound blueness around his lips and skin, accompanied by rapid, deep breathing and extreme irritability.
Which of the following is the most appropriate immediate first step in the management of this acute episode?
 
 
 
 

16.

A 45-year-old female with a body mass index (BMI) of 34 kg/m² presents to the general practice clinic seeking pharmacological management for weight loss. She has a history of type 2 diabetes and osteoarthritis, and has attempted diet and exercise modifications for the past year with minimal success. You are considering initiating therapy with semaglutide.
During the pre-prescription evaluation, which of the following elements in her personal or family history would represent a contraindication to the use of this medication?
 
 
 
 

17.

A 55-year-old male is successfully resuscitated in the emergency department after an out-of-hospital cardiac arrest due to ventricular fibrillation. He has return of spontaneous circulation (ROSC) but remains comatose and unresponsive.
Which of the following is the most appropriate goal in the immediate post-resuscitative management of this patient?
 
 
 
 

18.

A 30-year-old male presents to the clinic complaining of a highly painful sore on his penis that appeared 4 days ago. He recently returned from a vacation in the south-east Asia. Physical examination reveals a 1.5 cm shallow, soft ulcer with ragged, undermined edges and an erythematous border on the glans penis. You also note a notably enlarged, markedly tender, and fluctuant right inguinal lymph node (bubo).
Which of the following is the most appropriate first-line treatment for this patient’s suspected condition?
 
 
 
 

19.

A 26-year-old female presents to the general practice clinic complaining of irregular menstrual cycles, occurring every 2 to 3 months, and increasing dark facial hair over the past year. Her body mass index (BMI) is 32 kg/m². She states that she does not desire pregnancy at this time. Pelvic ultrasound reveals enlarged ovaries with multiple small cysts. You diagnose her with Polycystic Ovary Syndrome (PCOS).
In addition to recommending lifestyle modifications and weight loss, which of the following is the most appropriate first-line pharmacotherapy for this patient?
 
 
 
 

20.

A 48-year-old male with a long history of heavy alcohol use is hospitalized with severe acute alcoholic hepatitis. Laboratory investigations reveal a Maddrey discriminant function score of 38. Careful clinical evaluation confirms he has no concurrent infections, gastrointestinal bleeding, renal failure, or pancreatitis.
Which of the following is the most appropriate specific pharmacological therapy to initiate in this patient?